Article
Mutations in the N-glycan branching enzyme MGAT1 promote invasiveness and EGF-stimulated proliferation and adhesion in neuroblastoma cells.
PloS one - 1 Jan 2026
Hall M Kristen, Walker Lyla J, Messer Abel R, Schwalbe Ruth A
Abstract excerpt
Attachment and modification of N-glycans to proteins have been linked to the promotion of cancer, and specifically, more recent investigations have supported the involvement of less processed N-glycans. Herein, we investigated how reduced activity of N-acetylglucosaminyltransferase-I (GnT-I, MGAT1) influences aberrant cellular properties and epidermal growth factor receptor (EGFR) signaling in human NB cells....
Read the complete abstract on PubMedTopics
- Humans
- Cell Proliferation
- Cell Adhesion
- Epidermal Growth Factor
- N-Acetylglucosaminyltransferases
- Cell Line, Tumor