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Article

Increased expression of SSEA-4 on TKI-resistant non-small cell lung cancer with EGFR-T790M mutation.

Proceedings of the National Academy of Sciences of the United States of America - 30 Jan 2024

Chen Nai-Yu, Lin Chih-Wei, Lai Ting-Yen, Wu Chung-Yi, Liao Pei-Chi, Hsu Tsui-Ling, Wong Chi-Huey

Abstract excerpt

Non-small cell lung cancer (NSCLC), a major life-threatening disease accounting for 85% of all lung cancer cases, has been treated with tyrosine kinase inhibitors (TKIs), but often resulted in drug resistance, and approximately 60% of TKI-resistant cases are due to acquired secondary (epithelial growth factor receptor) EGFR-T790M mutation. To identify alternative targets for TKI-resistant NSCLC with EGFR-T790M...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38252815
DOI: 10.1073/pnas.2313397121
PMCID: PMC10835044

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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