Article

N-glycosylation of GSTO1 promotes cervical cancer migration and invasion through JAK/STAT3 pathway activation

2024-09-02

Abstract excerpt

<title>Abstract</title> <p>Background Protein glycosylation is strongly associated with tumor progression. Glutathione S-transferase omega 1 (GSTO1) is a member of the glutathione S-transferase family. The significance of GSTO1 N-glycosylation in the progression of cervical cancer (CC) has remained elusive. In this study, we investigated the functional significance of GSTO1 N-glycosylation in CC progression. Meth...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 67624f82-5781-5e59-ae29-e93594c0f8d1
DOI: 10.21203/rs.3.rs-4813636/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

N-glycosylation of GSTO1 promotes cervical cancer migration and invasion through JAK/STAT3 pathway activationDOI 10.21203/rs.3.rs-4813636/v1Read

Key Cancer Glycosylation-related Genes Analysis: Regulatory, Therapeutic, and Prognostic InsightsSemantic proximity Read

GALNT1 Enhances Malignant Phenotype of Gastric Cancer via Modulating CD44 Glycosylation to Activate the Wnt/β-catenin Signaling Pathway.Semantic proximity Read

Role of the polypeptide N-acetylgalactosaminyltransferase 3 in ovarian cancer progression: possible implications in abnormal mucin O-glycosylation.Semantic proximity Read

NEU4-mediated desialylation ignites the oncogenic receptors for the dissemination of ovarian carcinomaSemantic proximity Read

Bioinformatic analysis and in vitro experiments reveal that N-linked glycosylation related genes STT3A, DDOST and TMEM165 participate in the promotion of hepatocellular carcinoma and Its role in immunotherapySemantic proximity Read

Glyoxalase 1: emerging biomarker and therapeutic target in cervical cancer progressionSemantic proximity Read

Comprehensive Bioinformatics Analysis of Glycosylation-Related Genes and Potential Therapeutic Targets in Colorectal CancerSemantic proximity Read

Protein glycosylation in cancers and its potential therapeutic applications in neuroblastomaSemantic proximity Read

GALNT6 promotes bladder cancer malignancy and immune escape by epithelial-mesenchymal transition and CD8+T cellsSemantic proximity Read

Knockdown of GALNT1 suppresses malignant phenotype of hepatocellular carcinoma by suppressing EGFR signaling.Semantic proximity Read

O-GlcNAcylation promotes malignant phenotypes of bladder cancer cells.Semantic proximity Read

Molecular Subtypes of Esophageal Squamous Cell Carcinoma Driven by N- Glycosylation and Construction of a Machine Learning-Based Prognostic ModelSemantic proximity Read