Article

Widespread multi-targeted therapy resistance via drug-induced secretome fucosylation

2021-04-22

Abstract excerpt

Cancer secretome is a reservoir for aberrant glycosylation. How therapies alter this post-translational cancer hallmark and the consequences thereof remain elusive. Here we show that an elevated secretome fucosylation is a pan-cancer signature of both response and resistance to multiple targeted therapies. Large-scale pharmacogenomics revealed that fucosylation genes display widespread association with resistance...

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Identifiers and source

Literature Corpus work: 32fa9996-4ebb-5547-aa3e-bab3201d79c9
DOI: 10.1101/2021.04.21.440719

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