Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

B cell-intrinsic TLR7 expression drives severe lupus in TLR9-deficient mice.

JCI insight - 22 Aug 2023

Cosgrove Haylee A, Gingras Sebastien, Kim Minjung, Bastacky Sheldon, Tilstra Jeremy S, Shlomchik Mark J

Abstract excerpt

The endosomal Toll-like receptor 7 (TLR7) is a major driver of murine and human systemic lupus erythematosus (SLE). The role of TLR7 in lupus pathogenesis is enhanced when the regulatory role of TLR9 is absent. TLR7 signaling in plasmacytoid DCs (pDC) is generally thought to be a major driver of the IFN response and disease pathology; however, the cell types in which TLR7 acts to mediate disease have not been...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adjuvants, Immunologic
Share to Agammaglobulinemia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Alleles

Share to Lupus Erythematosus, Systemic

Share to Mice, Inbred MRL lpr

Share to Toll-Like Receptor 7

Share to Toll-Like Receptor 9

Source

Open in PubMed Open full text

Identifiers

PMID: 37606042
DOI: 10.1172/jci.insight.172219
PMCID: PMC10543715

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

B cell-intrinsic TLR7 expression drives severe lupus in TLR9-deficient mice.PMID 37606042Read ↗

B cell TLR7 expression drives anti-RNA autoantibody production and exacerbates disease in systemic lupus erythematosus-prone mice.Semantic proximity Read ↗

Opposing Impact of B Cell–Intrinsic TLR7 and TLR9 Signals on Autoantibody Repertoire and Systemic InflammationSemantic proximity Read ↗

TLR9 Regulates TLR7- and MyD88-Dependent Autoantibody Production and Disease in a Murine Model of LupusSemantic proximity Read ↗

Divergent TIR signaling domains in TLR7 and TLR9 control opposing effects on systemic autoimmunitySemantic proximity Read ↗

TLR9 Deficiency Leads to Accelerated Renal Disease and Myeloid Lineage Abnormalities in Pristane-Induced Murine LupusSemantic proximity Read ↗

B cell-intrinsic TLR7 signaling is essential for the development of spontaneous germinal centers.Semantic proximity Read ↗

Human and Murine Toll-like Receptor-Driven Disease in Systemic Lupus Erythematosus.Semantic proximity Read ↗

B cell autophagy mediates TLR7-dependent autoimmunity and inflammation.Semantic proximity Read ↗

Toll-like Receptor 7 and TLR9 Dictate Autoantibody Specificity and Have Opposing Inflammatory and Regulatory Roles in a Murine Model of LupusSemantic proximity Read ↗

Exacerbated Autoimmunity in the Absence of TLR9 in MRL. <i>Faslpr</i> Mice Depends on <i>Ifnar1</i>Semantic proximity Read ↗

Monogenic autoimmunity caused by TLR7 gain-of-functionSemantic proximity Read ↗

Investigating cytotoxic and inflammatory human IL-7 receptor low effector memory CD8+ T cells in lupusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.