Article
IRAP+ endosomes restrict TLR9 activation and signaling.
Nature immunology - 1 May 2017
Babdor Joel, Descamps Delphyne, Adiko Aimé Cézaire, Tohmé Mira, Maschalidi Sophia, Evnouchidou Irini, Vasconcellos Luiz Ricardo, De Luca Mariacristina, Mauvais Francois-Xavier, Garfa-Traore Meriem, Brinkmann Melanie M, Chignard Michel, Manoury Bénédicte, Saveanu Loredana
Abstract excerpt
The retention of intracellular Toll-like receptors (TLRs) in the endoplasmic reticulum prevents their activation under basal conditions. TLR9 is activated by sensing ligands in specific endosomal-lysosomal compartments. Here we identified IRAP+ endosomes as major cellular compartments for the early steps of TLR9 activation in dendritic cells (DCs). Both TLR9 and its ligand, the dinucleotide CpG, were present as...
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