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Article

Identification of an N-terminal recognition site in TLR9 that contributes to CpG-DNA-mediated receptor activation.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2009

Peter Mirjam E, Kubarenko Andriy V, Weber Alexander N R, Dalpke Alexander H

Abstract excerpt

Although it is well established that TLR9 recognizes CpG-DNA, the structural details of ligand-receptor interaction are still mostly unknown. The extracellular domain of TLR9 is composed of 25 leucine-rich repeat (LRR) motifs, 5 of which bear inserting sequences that do not conform to the LRR consensus motif. In this study, we show that the functional integrity of the extracellular domain of murine TLR9 is lost...

Read the complete abstract on PubMed

Topics

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Share to Conserved Sequence
Share to CpG Islands

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Deletion

Share to Leucine

Share to Sequence Alignment

Share to Structural Homology, Protein

Share to Toll-Like Receptor 3

Share to Toll-Like Receptor 9

Source

Identifiers

PMID: 19494293
DOI: 10.4049/jimmunol.0900819

Genes

TLR9
TLR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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