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Article

Analysis of causal effect of APOA5 variants on premature coronary artery disease.

Annals of human genetics - 1 Nov 2018

Wang Fan, Wang Isabel Z, Ellis Stephen, Archacki Stephen, Barnard John, Hubbard Carlos, Topol Eric J, Chen Qiuyun, Wang Qing K

Abstract excerpt

Apolipoprotein A5 (APOA5) regulates the metabolisms of triglyceride and HDL. APOA5 variants have been linked to coronary artery disease (CAD), but their causal roles are not well studied yet. This study aims to identify the causal effects of APOA5 variants on premature CAD. Sequencing analysis of APOA5 in 128 premature, familiar CAD patients from GeneQuest identified 11 genomic variants, including p.S19W...

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Source

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Identifiers

PMID: 30024021
DOI: 10.1111/ahg.12273
PMCID: PMC6188800

Genes

CAD
APOA5

Variants

rs3135506

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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