Article
Genome-wide association study identifies a missense variant at APOA5 for coronary artery disease in Multi-Ethnic Cohorts from Southeast Asia.
Scientific reports - 20 Dec 2017
Han Yi, Dorajoo Rajkumar, Chang Xuling, Wang Ling, Khor Chiea-Chuen, Sim Xueling, Cheng Ching-Yu, Shi Yuan, Tham Yih Chung, Zhao Wanting, Chee Miao Ling, Sabanayagam Charumathi, Chee Miao Li, Tan Nicholas, Wong Tien Yin, Tai E-Shyong, Liu Jianjun, Goh Daniel Y T, Yuan Jian-Min, Koh Woon-Puay, van Dam Rob M, Low Adrian F, Chan Mark Yan-Yee, Friedlander Yechiel, Heng Chew-Kiat
Abstract excerpt
Recent genome-wide association studies (GWAS) have identified multiple loci associated with coronary artery disease (CAD) among predominantly Europeans. However, their relevance to multi-ethnic populations from Southeast Asia is largely unknown. We performed a meta-analysis of four GWAS comprising three Chinese studies and one Malay study (Total N = 2,169 CAD cases and 7,376 controls). Top hits (P < 5 × 10-8)...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.