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Article

A functional variant in APOA5/A4/C3/A1 gene cluster contributes to elevated triglycerides and severity of CAD by interfering with microRNA 3201 binding efficiency.

Journal of the American College of Cardiology - 22 Jul 2014

Cui Guanglin, Li Zongzhe, Li Rui, Huang Jin, Wang Haoran, Zhang Lina, Ding Hu, Wang Dao Wen

Abstract excerpt

BACKGROUND: Recent genome-wide association studies identified the APOA5/A4/C3/A1 gene cluster polymorphisms influencing triglyceride level and risk of coronary artery disease (CAD). OBJECTIVES: The purposes of this study were to fine-map triglyceride association signals in the APOA5/A4/C3/A1 gene cluster and then explore the clinical relevance in CAD and potential underlying mechanisms. METHODS: We resequenced...

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Source

Identifiers

PMID: 25034063
DOI: 10.1016/j.jacc.2014.03.050

Genes

APOA5
CAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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