Article
The HIF1A rs2057482 polymorphism is associated with risk of developing premature coronary artery disease and with some metabolic and cardiovascular risk factors. The Genetics of Atherosclerotic Disease (GEA) Mexican Study.
Experimental and molecular pathology - 1 Jun 2014
López-Reyes Alberto, Rodríguez-Pérez José Manuel, Fernández-Torres Javier, Martínez-Rodríguez Nancy, Pérez-Hernández Nonanzit, Fuentes-Gómez Arturo Javier, Aguilar-González Carlos Alberto, Alvarez-León Edith, Posadas-Romero Carlos, Villarreal-Molina Teresa, Pineda Carlos, Vargas-Alarcón Gilberto
Abstract excerpt
The aim of the present study was to establish the role of HIF1A gene polymorphisms in the risk of developing premature coronary artery disease (CAD) in a well-characterized clinical cohort. Three polymorphisms in HIF1A (rs11549465, rs11549467, rs2057482) gene were genotyped in 949 patients with premature CAD, and 676 healthy controls (with negative calcium score by computed tomography). Under a dominant model...
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