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Article

Contribution of genetic variants in the development of familial premature coronary artery disease in a cohort of cardiac patients.

Clinical genetics - 1 Jun 2024

Mehvari Sepideh, Karimian Fathi Nahid, Saki Sara, Asadnezhad Maryam, Arzhangi Sanaz, Ghodratpour Fatemeh, Mohseni Marzieh, Zare Ashrafi Farzane, Sadeghian Saeed, Boroumand Mohammadali, Shokohizadeh Fatemeh, Rostami Elham, Boroumand Rahnama, Najafipour Reza, Malekzadeh Reza, Riazalhosseini Yasser, Akbari Mohammadreza, Lathrop Mark, Najmabadi Hossein, Hosseini Kaveh, Kahrizi Kimia

Abstract excerpt

Coronary artery disease (CAD), the most prevalent cardiovascular disease, is the leading cause of death worldwide. Heritable factors play a significant role in the pathogenesis of CAD. It has been proposed that approximately one-third of patients with CAD have a positive family history, and individuals with such history are at ~1.5-fold increased risk of CAD in their lifespans. Accordingly, the long-recognized...

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Identifiers

PMID: 38308583
DOI: 10.1111/cge.14491

Genes

CAD
PIK3C2G
RASSF9
ZFYVE21
ABCG8
CD36
CYP27A1
RYR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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