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Article

The pore, not cytoplasmic domains, underlies inactivation in a prokaryotic sodium channel.

Biophysical journal - 1 Jul 2005

Pavlov Evgeny, Bladen Christopher, Winkfein Robert, Diao Catherine, Dhaliwal Perry, French Robert J

Abstract excerpt

Kinetics and voltage dependence of inactivation of a prokaryotic voltage-gated sodium channel (NaChBac) were investigated in an effort to understand its molecular mechanism. NaChBac inactivation kinetics show strong, bell-shaped voltage dependence with characteristic time constants ranging from approximately 50 ms at depolarized voltages to a maximum of approximately 100 s at the inactivation midpoint. Activation...

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Identifiers

PMID: 15849254
DOI: 10.1529/biophysj.104.056994
PMCID: PMC1366521

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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