Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genes and pathways underlying regional and cell type changes in Alzheimer's disease

25 May 2013

Abstract excerpt

BACKGROUND: Transcriptional studies suggest Alzheimer's disease (AD) involves dysfunction of many cellular pathways, including synaptic transmission, cytoskeletal dynamics, energetics, and apoptosis. Despite known progression of AD pathologies, it is unclear how such striking regional vulnerability occurs, or which genes play causative roles in disease progression. METHODS: To address these issues, we performed a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Dementia and Cognitive Impairment Research
Share to Neuroinflammation and Neurodegeneration Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23705665
DOI: 10.1186/gm452

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genes and pathways underlying regional and cell type changes in Alzheimer's diseasePMID 23705665Read ↗

Spatial transcriptomic patterns underlying amyloid-β and tau pathology are associated with cognitive dysfunction in Alzheimer’s diseaseSemantic proximity Read ↗

Systematic Analysis of Biological Processes Reveals Gene Co-expression Modules Driving Pathway Dysregulation in Alzheimer’s DiseaseSemantic proximity Read ↗

Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer's disease.Semantic proximity Read ↗

Spatial transcriptomic patterns underlying regional vulnerability to amyloid-β and tau pathologies and their relationships to cognitive dysfunction in Alzheimer’s diseaseSemantic proximity Read ↗

Spatially resolved transcriptomics reveals unique gene signatures associated with human temporal cortical architecture and Alzheimer’s pathologySemantic proximity Read ↗

Weighted Gene Co-expression Network Analysis Reveals Functionally Coherent Gene Networks Associated with Alzheimer’s Disease PathologySemantic proximity Read ↗

Differentially expressed genes in Alzheimer’s disease highlighting the roles of microglia genes including OLR1 and astrocyte gene CDK2AP1Semantic proximity Read ↗

Integrative genomics approach identifies conserved transcriptomic networks in Alzheimer’s diseaseSemantic proximity Read ↗

Alzheimer’s disease rewires gene coexpression networks coupling different brain regionsSemantic proximity Read ↗

A single cell brain atlas in human Alzheimer’s diseaseSemantic proximity Read ↗

Integrating Gene and Protein Expression Reveals Perturbed Functional Networks in Alzheimer’s DiseaseSemantic proximity Read ↗

Consistent Genes Associated With Structural Changes in Clinical Alzheimer’s Disease SpectrumSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.