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Article

FOXP3 Activates SUMO-Conjugating UBC9 Gene in MCF7 Breast Cancer Cells.

International journal of molecular sciences - 13 Jul 2018

Wang Chiung-Min, Yang William H, Liu Runhua, Wang Lizhong, Yang Wei-Hsiung

Abstract excerpt

Forkhead Box Protein P3 (FOXP3), a transcription factor of the FOX protein family, is essentially involved in the development of regulatory T (Treg) cells, and functions as a tumor suppressor. Although FOXP3 has been widely studied in immune system and cancer development, its function in the regulation of the UBC9 gene (for the sole E2 enzyme of SUMOylation) is unknown. Herein, we find that the overexpression of...

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Source

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Identifiers

PMID: 30011797
DOI: 10.3390/ijms19072036
PMCID: PMC6073147

Genes

FOXP3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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