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Article

FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene.

Cell - 29 Jun 2007

Zuo Tao, Wang Lizhong, Morrison Carl, Chang Xing, Zhang Huiming, Li Weiquan, Liu Yan, Wang Yin, Liu Xingluo, Chan Michael W Y, Liu Jin-Qing, Love Richard, Liu Chang-Gong, Godfrey Virginia, Shen Rulong, Huang Tim H-M, Yang Tianyu, Park Bae Keun, Wang Cun-Yu, Zheng Pan, Liu Yang

Abstract excerpt

The X-linked Foxp3 is a member of the forkhead/winged helix transcription factor family. Germline mutations cause lethal autoimmune diseases in males. Serendipitously, we observed that female mice heterozygous for the "scurfin" mutation of the Foxp3 gene (Foxp3(sf/+)) developed cancer at a high r...

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Share to Carcinoma
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Forkhead Transcription Factors

Share to Genes, erbB-2

Share to Genes, X-Linked

Share to Mammary Neoplasms, Experimental

Share to Receptor, ErbB-2

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Source

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Identifiers

PMID: 17570480
DOI: 10.1016/j.cell.2007.04.034
PMCID: PMC1974845

Genes

FOXP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17570480-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene.PMID 17570480Read ↗

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The Scurfy mutation of FoxP3 in the thymus stroma leads to defective thymopoiesis.Semantic proximity Read ↗

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