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Article

FOXP3 is a novel transcriptional repressor for the breast cancer oncogene SKP2

15 Nov 2007

Abstract excerpt

S-phase kinase-associated protein 2 (SKP2) is a component of the E3 ubiquitin ligase SKP1-Cul1-Fbox complex. Overexpression of SKP2 results in cell cycle dysregulation and carcinogenesis; however, the genetic lesions that cause this upregulation are poorly understood. We recently demonstrated that forkhead box P3 (FOXP3) is an X-linked breast cancer suppressor and an important repressor of the oncogene...

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PMID: 18008005
DOI: 10.1172/jci32538

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