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Article

PBRM1 bromodomains variably influence nucleosome interactions and cellular function.

The Journal of biological chemistry - 31 Aug 2018

Slaughter Mariesa J, Shanle Erin K, McFadden Andrew W, Hollis Emily S, Suttle Lindsey E, Strahl Brian D, Davis Ian J

Abstract excerpt

Chromatin remodelers use bromodomains (BDs) to recognize histones. Polybromo 1 (PBRM1 or BAF180) is hypothesized to function as the nucleosome-recognition subunit of the PBAF chromatin-remodeling complex and is frequently mutated in clear cell renal cell carcinoma (ccRCC). Previous studies have applied in vitro methods to explore the binding specificities of the six individual PBRM1 BDs. However, BD targeting to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29986887
DOI: 10.1074/jbc.RA118.003381
PMCID: PMC6120218

Genes

PBRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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