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Article

Loss of PBRM1 expression is associated with renal cell carcinoma progression.

International journal of cancer - 15 Jan 2013

Pawłowski Rafal, Mühl Sarah M, Sulser Tullio, Krek Wilhelm, Moch Holger, Schraml Peter

Abstract excerpt

Although von Hippel-Lindau (VHL) tumor suppressor gene alterations dominate the genetic landscape of clear cell renal cell carcinoma (ccRCC), recent studies have identified new ccRCC genes, including SETD2, KDM6A, KDM5C, BAP1 and PBRM1. Strikingly, all these genes fall into a category of histone/chromatin regulators. Polybromo-1 (PBRM1) is the second most frequently mutated gene after VHL; however, the clinical...

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Share to Carcinoma, Renal Cell
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Source

Identifiers

PMID: 22949125
DOI: 10.1002/ijc.27822

Genes

PBRM1
VHL
BAP1
SETD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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