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Article

Status of KRAS in iPSCs Impacts upon Self-Renewal and Differentiation Propensity.

Stem cell reports - 14 Aug 2018

Kubara Kenji, Yamazaki Kazuto, Ishihara Yasuharu, Naruto Takuya, Lin Huan-Ting, Nishimura Ken, Ohtaka Manami, Nakanishi Mahito, Ito Masashi, Tsukahara Kappei, Morio Tomohiro, Takagi Masatoshi, Otsu Makoto

Abstract excerpt

Oncogenic KRAS mutations in hematopoietic stem cells cause RAS-associated autoimmune lymphoproliferative syndrome-like disease (RALD). KRAS plays essential roles in stemness maintenance in some types of stem cells. However, its roles in pluripotent stem cells (PSCs) are poorly understood. Here, we investigated the roles of KRAS on stemness in the context of induced PSCs (iPSCs). We used KRAS mutant (G13C/WT) and...

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Share to Autoimmune Lymphoproliferative Syndrome
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29983389
DOI: 10.1016/j.stemcr.2018.06.008
PMCID: PMC6092694

Genes

KRAS

Variants

Provenance

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