Back to search

Article

STAT3 Sustains Tumorigenicity Following Mutant KRAS Ablation

2025-02-27

Abstract excerpt

Oncogenic KRAS mutations underlie some of the deadliest human cancers. Genetic or pharmacological inactivation of mutant KRAS is not sufficient for long-term control of advanced tumors. Using a conceptual framework of pancreatic ductal adenocarcinoma, we find that CRISPR-mediated ablation of mutant KRAS can terminate tumor progression contingent on the concomitant inactivation of STAT3. STAT3 inactivation is neede...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
9a7d3488-9768-5b77-ba8a-0f6ac287fda0
DOI
10.1101/2025.02.21.639533
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
STAT3 Sustains Tumorigenicity Following Mutant KRAS AblationDOI 10.1101/2025.02.21.639533
STAT3 sustains tumorigenicity following mutant KRAS ablation.Semantic proximity
STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis.Semantic proximity
Survival of pancreatic cancer cells lacking KRAS functionSemantic proximity
STAT3 is a genetic modifier of TGF-beta induced EMT in KRAS mutant pancreatic cancerSemantic proximity
STAT3 is a genetic modifier of TGF-beta induced EMT in KRAS mutant pancreatic cancerSemantic proximity
SHANK3 depletion leads to ERK signalling overdose and cell death in KRAS-mutant cancers.Semantic proximity
Molecular dynamics driving phenotypic divergence among KRAS mutants in pancreatic tumorigenesis.Semantic proximity
KRAS drives immune evasion in a genetic model of pancreatic cancerSemantic proximity
Molecular dynamics driving phenotypic divergence among KRAS mutants in pancreatic tumorigenesisSemantic proximity
The Extracellular Niche and Tumor Microenvironment Enhance KRAS Inhibitor Efficacy in Pancreatic Cancer.Semantic proximity
Roles for KRAS in pancreatic tumor development and progression.Semantic proximity
Distinct small molecule inhibitors of Kras specifically prime CTLA4 blockade therapy to transcriptionally reprogram Tregs and overcome resistance to suppress pancreas cancerSemantic proximity
Select a neighboring publication to make it the new centre.