Article

Monoallelic KRAS (G13C) mutation triggers dysregulated expansion in induced pluripotent stem cell-derived hematopoietic progenitor cells

2023-07-13

Abstract excerpt

<title>Abstract</title> <bold>Background:</bold> Although oncogenic RAS mutants are thought to exert mutagenic effects upon blood cells, it remains uncertain how a single oncogenic <italic>RAS</italic> impacts non-transformed hematopoietic progenitor cells (HPCs). Such potential pre-malignant status may characterize HPCs in patients with RAS-associated autoimmune lymphoproliferative syndrome-like disease (RALD...

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Literature Corpus work: e093c73f-2a41-5170-92b5-24baff4f1923
DOI: 10.21203/rs.3.rs-2513069/v1

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