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Article

RAS isoform specific activities are disrupted by disease associated mutations during cell differentiation.

European journal of cell biology - 1 Jun 2024

Chippalkatti Rohan, Parisi Bianca, Kouzi Farah, Laurini Christina, Ben Fredj Nesrine, Abankwa Daniel Kwaku

Abstract excerpt

The RAS-MAPK-pathway is aberrantly regulated in cancer and developmental diseases called RASopathies. While typically the impact of Ras on the proliferation of various cancer cell lines is assessed, it is poorly established how Ras affects cellular differentiation. Here we implement the C2C12 myoblast cell line to systematically study the effect of Ras mutants and Ras-pathway drugs on differentiation. We first...

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Identifiers

PMID: 38795504
DOI: 10.1016/j.ejcb.2024.151425

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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