Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Monoallelic KRAS (G13C) mutation triggers dysregulated expansion in induced pluripotent stem cell-derived hematopoietic progenitor cells.

Stem cell research & therapy - 16 Apr 2024

Lin Huan-Ting, Takagi Masatoshi, Kubara Kenji, Yamazaki Kazuto, Michikawa Fumiko, Okumura Takashi, Naruto Takuya, Morio Tomohiro, Miyazaki Koji, Taniguchi Hideki, Otsu Makoto

Abstract excerpt

BACKGROUND: Although oncogenic RAS mutants are thought to exert mutagenic effects upon blood cells, it remains uncertain how a single oncogenic RAS impacts non-transformed multipotent hematopoietic stem or progenitor cells (HPCs). Such potential pre-malignant status may characterize HPCs in patients with RAS-associated autoimmune lymphoproliferative syndrome-like disease (RALD). This study sought to elucidate the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Differentiation
Share to Hematopoietic Stem Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Induced Pluripotent Stem Cells

Share to Mutation

Share to Proto-Oncogene Proteins p21(ras)

Source

Open in PubMed Open full text

Identifiers

PMID: 38627844
DOI: 10.1186/s13287-024-03723-2
PMCID: PMC11021011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Monoallelic KRAS (G13C) mutation triggers dysregulated expansion in induced pluripotent stem cell-derived hematopoietic progenitor cells.PMID 38627844Read ↗

Monoallelic KRAS (G13C) mutation triggers dysregulated expansion in induced pluripotent stem cell-derived hematopoietic progenitor cellsSemantic proximity Read ↗

Status of KRAS in iPSCs Impacts upon Self-Renewal and Differentiation Propensity.Semantic proximity Read ↗

Generation of a genetically-modified induced pluripotent stem cell line harboring an oncogenic gene variant KRAS p.G12V.Semantic proximity Read ↗

Oncogenic Kras Initiates Leukemia in Hematopoietic Stem CellsSemantic proximity Read ↗

Leukemogenic Kras mutation reprograms multipotent progenitors to facilitate its spread through the hematopoietic system.Semantic proximity Read ↗

KRAS and RAS-MAPK Pathway Deregulation in Mature B Cell Lymphoproliferative DisordersSemantic proximity Read ↗

Idiopathic splenomegaly in childhood and the spectrum of RAS-associated lymphoproliferative disease: a case report.Semantic proximity Read ↗

Oncogenic KrasG12D Activation in the Nonhematopoietic Bone Marrow Microenvironment Causes Myelodysplastic Syndrome in Mice.Semantic proximity Read ↗

Isolated KRAS and NRAS mutations in adults with monocytosis and/or cytopenia(s).Semantic proximity Read ↗

Oncogenic N-Ras Mitigates Oxidative Stress–Induced Apoptosis of Hematopoietic Stem CellsSemantic proximity Read ↗

The importance of considering monogenic causes of autoimmunity: A somatic mutation in KRAS causing pediatric Rosai-Dorfman syndrome and systemic lupus erythematosus.Semantic proximity Read ↗

Pdx1 expression in hematopoietic cells activates Kras-mutation to drive leukemia in KC (Pdx1-Cre; LSL-KrasG12D/+) mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.