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Article

Recapitulating primary immunodeficiencies with expanded potential stem cells: Proof of concept with STAT1 gain of function.

The Journal of allergy and clinical immunology - 1 Apr 2024

Liu Xueyan, Chan Vera S F, Smith Kenneth G C, Ming Chang, Or Chung Sze, Tsui Faria T W, Gao Bo, Cook Matthew C, Liu Pentao, Lau Chak Sing, Li Philip Hei

Abstract excerpt

BACKGROUND: Inborn errors of immunity (IEI) often lack specific disease models and personalized management. Signal transducer and activator of transcription (STAT)-1 gain of function (GoF) is such example of an IEI with diverse clinical phenotype with unclear pathomechanisms and unpredictable response to therapy. Limitations in obtaining fresh samples for functional testing and research further highlights the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38072195
DOI: 10.1016/j.jaci.2023.11.914
PMCID: PMC7619439

Genes

STAT1
APOL6
OAS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Recapitulating primary immunodeficiencies with expanded potential stem cells: Proof of concept with STAT1 gain of function.PMID 38072195Read ↗

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