Influence of a Coronary Artery Disease-Associated Genetic Variant on FURIN Expression and Effect of Furin on Macrophage Behavior.

doi:10.1161/ATVBAHA.118.311030

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Article

Influence of a Coronary Artery Disease-Associated Genetic Variant on FURIN Expression and Effect of Furin on Macrophage Behavior.

Arteriosclerosis, thrombosis, and vascular biology - 1 Aug 2018

Zhao Guojun, Yang Wei, Wu Jingchun, Chen Bairu, Yang Xu, Chen Junhui, McVey David G, Andreadi Catherine, Gong Peng, Webb Tom R, Samani Nilesh J, Ye Shu

Abstract excerpt

Objective- Genome-wide association studies have revealed a robust association between genetic variation on chromosome 15q26.1 and coronary artery disease (CAD) susceptibility; however, the underlying biological mechanism is still unknown. The lead CAD-associated genetic variant (rs17514846) at this locus resides in the FURIN gene. In advanced atherosclerotic plaques, furin is expressed primarily in macrophages....

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PMID: 29976768
DOI: 10.1161/ATVBAHA.118.311030
PMCID: PMC6092112

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CAD
FURIN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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