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Article

Genotype-dependent metabolic and inflammatory regulation at the ANRIL locus in human primary macrophages.

Molecular genetics and genomics : MGG - 19 Jun 2026

Kirsan-Kesici Cemre Buse, Ozuynuk-Ertugrul Aybike Sena, Komurcu-Bayrak Evrim, Coban Neslihan

Abstract excerpt

The long non-coding RNA ANRIL and several single-nucleotide polymorphisms have been strongly implicated in genetic susceptibility to coronary artery disease (CAD). However, how these variants influence gene expression remains incompletely understood. This study aims to investigate genotype-dependent differences in linear and circular ANRIL isoform expression and selected CAD- and diabetes-related genes in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42319513
DOI: 10.1007/s00438-026-02454-8

Genes

CAD
PPARGC1A
ABCA1
CDKN2A
PRKAA1
TNFAIP3
CDKN2B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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