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Article

FURIN Expression in Vascular Endothelial Cells Is Modulated by a Coronary Artery Disease-Associated Genetic Variant and Influences Monocyte Transendothelial Migration.

Journal of the American Heart Association - 18 Feb 2020

Yang Xu, Yang Wei, McVey David G, Zhao Guojun, Hu Jinfu, Poston Robin N, Ren Meixia, Willeit Karin, Coassin Stefan, Willeit Johann, Webb Thomas R, Samani Nilesh J, Mayr Manuel, Kiechl Stefan, Ye Shu

Abstract excerpt

Background Genome-wide association studies have shown an association between the single-nucleotide polymorphism rs17514846 on chromosome 15q26.1 and coronary artery disease susceptibility. The underlying biological mechanism is, however, not fully understood. rs17514846 is located in the FES Upstream Region (FURIN) gene, which is expressed in vascular endothelial cells (ECs). We investigated whether rs17514846...

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Source

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Identifiers

PMID: 32067586
DOI: 10.1161/JAHA.119.014333
PMCID: PMC7070217

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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