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Article

Impact of bitter taste receptor phenotype upon clinical presentation in chronic rhinosinusitis.

International forum of allergy & rhinology - 1 Sept 2018

Rowan Nicholas R, Soler Zachary M, Othieno Florence, Storck Kristina A, Smith Timothy L, Schlosser Rodney J

Abstract excerpt

BACKGROUND: Genetic variation of the bitter taste receptor T2R38 has been associated with recalcitrant chronic rhinosinusitis (CRS). Specific T2R38 polymorphisms, correlating with bitter taste sensitivity to phenylthiocarbamide (PTC), have been identified as an independent risk factor for surgical intervention in CRS patients without polyps; however, the exact role of PTC tasting ability in clinical practice...

Topics

Adult
Aged
Cross-Sectional Studies
Female
Genetic Markers
Humans
Male
Middle Aged
Nasal Polyps
Phenotype
Phenylthiourea
Rhinitis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sinusitis

Smell

Taste

Source

Open in PubMed Open full text

Identifiers

PMID: 29972727
DOI: 10.1002/alr.22138
PMCID: PMC6538280

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-29972727-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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