Article
TAS2R38 genotype predicts surgical outcome in nonpolypoid chronic rhinosinusitis.
International forum of allergy & rhinology - 1 Jan 2016
Adappa Nithin D, Farquhar Douglas, Palmer James N, Kennedy David W, Doghramji Laurel, Morris Shane A, Owens David, Mansfield Corrine, Lysenko Anna, Lee Robert J, Cowart Beverly J, Reed Danielle R, Cohen Noam A
Abstract excerpt
BACKGROUND: Over 550,000 sinus surgeries are performed annually in the United States on patients with chronic rhinosinusitis (CRS). Although the results of sinus surgery vary widely, no known genetic factor has been identified to predict surgical outcomes. The bitter taste receptor T2R38 has recently been demonstrated to regulate upper airway innate defense and may affect patient responses to therapy. Our goal...
Topics
- Adult
- Aged
- Female
- Follow-Up Studies
- Genetic Markers
- Genotype
- Humans
- Male
- Middle Aged
- Phenotype
- Polymorphism, Genetic