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Article

Taste Receptor Polymorphisms and Immune Response: A Review of Receptor Genotypic-Phenotypic Variations and Their Relevance to Chronic Rhinosinusitis.

Frontiers in cellular and infection microbiology - 1 Jan 2018

Triantafillou Vasiliki, Workman Alan D, Kohanski Michael A, Cohen Noam A

Abstract excerpt

Bitter (T2R) and sweet taste (T1R) receptors have emerged as regulators of upper airway immune responses. Genetic variation of these taste receptors additionally confers susceptibility to infection and has been implicated in severity of disease in chronic rhinosinusitis (CRS). Ongoing taste receptor research has identified a variety of biologically active compounds that activate T1R and T2R receptors, increasing...

Topics

Chronic Disease
Genetic Variation
Genotype
Host-Pathogen Interactions
Humans
Immunity, Innate
Nasal Mucosa
Phenotype
Polymorphism, Genetic
Protein Isoforms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, G-Protein-Coupled

Rhinitis

Sinusitis

Taste Buds

Taste Receptors, Type 2

Source

Open in PubMed Open full text

Identifiers

PMID: 29564227
DOI: 10.3389/fcimb.2018.00064
PMCID: PMC5845873

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-29564227-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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