Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Novel Human Podocyte Cell Model Carrying G2/G2 APOL1 High-Risk Genotype.

Cells - 28 Jul 2021

Ekulu Pepe M, Adebayo Oyindamola C, Decuypere Jean-Paul, Bellucci Linda, Elmonem Mohamed A, Nkoy Agathe B, Mekahli Djalila, Bussolati Benedetta, van den Heuvel Lambertus P, Arcolino Fanny O, Levtchenko Elena N

Abstract excerpt

Apolipoprotein L1 (APOL1) high-risk genotypes (HRG), G1 and G2, increase the risk of various non-diabetic kidney diseases in the African population. To date, the precise mechanisms by which APOL1 risk variants induce injury on podocytes and other kidney cells remain unclear. Trying to unravel these mechanisms, most studies have used animal or cell models created by gene editing. We developed and characterised...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytoskeleton
Share to Kidney Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Apolipoprotein L1

Share to Autophagy

Share to Cell Adhesion

Share to Podocytes

Share to Poly I-C

Share to Up-Regulation

Source

Open in PubMed Open full text

Identifiers

PMID: 34440683
DOI: 10.3390/cells10081914
PMCID: PMC8391400

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Novel Human Podocyte Cell Model Carrying G2/G2 APOL1 High-Risk Genotype.PMID 34440683Read ↗

APOL1 risk variants cause podocytes injury through enhancing endoplasmic reticulum stress.Semantic proximity Read ↗

APOL1 risk variants enhance podocyte necrosis through compromising lysosomal membrane permeability.Semantic proximity Read ↗

Recruitment of APOL1 kidney disease risk variants to lipid droplets attenuates cell toxicitySemantic proximity Read ↗

APOL1 and kidney cell functionSemantic proximity Read ↗

Transcriptomic Analysis of Human Podocytes In Vitro: Effects of Differentiation and APOL1 GenotypeSemantic proximity Read ↗

Genome-wide screen identifies peroxisomal role in APOL1 podocytopathy.Semantic proximity Read ↗

Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice.Semantic proximity Read ↗

APOL1-G0 or APOL1-G2 Transgenic Models Develop Preeclampsia but Not Kidney DiseaseSemantic proximity Read ↗

APOL1-Mediated Cell Injury Involves Disruption of Conserved Trafficking Processes.Semantic proximity Read ↗

APOL1-mediated monovalent cation transport contributes to APOL1-mediated podocytopathy in kidney disease.Semantic proximity Read ↗

Genomewide Screen Identifies Peroxisomal Role in APOL1 PodocytopathySemantic proximity Read ↗

Disruption of APOL1-miR193a Axis Induces Disorganization of Podocyte Actin CytoskeletonSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.