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Article

Protein domains of APOL1 and its risk variants.

Experimental and molecular pathology - 1 Aug 2015

Lan Xiqian, Wen Hongxiu, Lederman Rivka, Malhotra Ashwani, Mikulak Joanna, Popik Waldemar, Skorecki Karl, Singhal Pravin C

Abstract excerpt

Increasing lines of evidence have demonstrated that the development of higher rates of non-diabetic glomerulosclerosis (GS) in African Americans can be attributed to two coding sequence variants (G1 and G2) in the Apolipoprotein L1 (APOL) gene. Recent studies indicate that the gene products of these APOL1 risk variants have augmented toxicity to kidney cells. However, the biological characteristics of APOL1 and...

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Source

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Identifiers

PMID: 26091559
DOI: 10.1016/j.yexmp.2015.06.003
PMCID: PMC4509982

Genes

APOL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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