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Article

A splenic IgM memory subset with antibacterial specificities is sustained from persistent mucosal responses.

The Journal of experimental medicine - 6 Aug 2018

Le Gallou Simon, Zhou Zhicheng, Thai Lan-Huong, Fritzen Remi, de Los Aires Alba Verge, Mégret Jérôme, Yu Philipp, Kitamura Daisuke, Bille Emmanuelle, Tros Fabiola, Nassif Xavier, Charbit Alain, Weller Sandra, Weill Jean-Claude, Reynaud Claude-Agnès

Abstract excerpt

To what extent immune responses against the gut flora are compartmentalized within mucosal tissues in homeostatic conditions remains a much-debated issue. We describe here, based on an inducible AID fate-mapping mouse model, that systemic memory B cell subsets, including mainly IgM+ B cells in spleen, together with IgA+ plasma cells in spleen and bone marrow, are generated in mice in the absence of deliberate...

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Identifiers

PMID: 29959173
DOI: 10.1084/jem.20180977
PMCID: PMC6080908

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