Article
Diversification of memory B cells drives the continuous adaptation of secretory antibodies to gut microbiota.
Nature immunology - 1 Aug 2015
Lindner Cornelia, Thomsen Irene, Wahl Benjamin, Ugur Milas, Sethi Maya K, Friedrichsen Michaela, Smoczek Anna, Ott Stephan, Baumann Ulrich, Suerbaum Sebastian, Schreiber Stefan, Bleich André, Gaboriau-Routhiau Valérie, Cerf-Bensussan Nadine, Hazanov Helena, Mehr Ramit, Boysen Preben, Rosenstiel Philip, Pabst Oliver
Abstract excerpt
Secretory immunoglobulin A (SIgA) shields the gut epithelium from luminal antigens and contributes to host-microbe symbiosis. However, how antibody responses are regulated to achieve sustained host-microbe interactions is unknown. We found that mice and humans exhibited longitudinal persistence of clonally related B cells in the IgA repertoire despite major changes in the microbiota during antibiotic treatment or...
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