Article
Different B cell populations mediate early and late memory during an endogenous immune response.
Science (New York, N.Y.) - 4 Mar 2011
Pape Kathryn A, Taylor Justin J, Maul Robert W, Gearhart Patricia J, Jenkins Marc K
Abstract excerpt
Memory B cells formed in response to microbial antigens provide immunity to later infections; however, the inability to detect rare endogenous antigen-specific cells limits current understanding of this process. Using an antigen-based technique to enrich these cells, we found that immunization with a model protein generated B memory cells that expressed isotype-switched immunoglobulins (swIg) or retained IgM. The...
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