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Article

Effect of P450 Oxidoreductase Polymorphisms on the Metabolic Activities of Ten Cytochrome P450s Varied by Polymorphic CYP Genotypes in Human Liver Microsomes.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology - 1 Jan 2018

Fang Yan, Gao Na, Tian Xin, Zhou Jun, Zhang Hai-Feng, Gao Jie, He Xiao-Pei, Wen Qiang, Jia Lin-Jing, Jin Han, Qiao Hai-Ling

Abstract excerpt

Background/ Aims: Little is known about the effect of P450 oxidoreductase (POR) gene polymorphisms on the activities of CYPs with multiple genotypes. METHODS: We genotyped 102 human livers for 18 known POR single nucleotide polymorphisms (SNPs) with allelic frequencies greater than 1% as well as for 27 known SNPs in 10 CYPs. CYP enzyme activities in microsomes prepared from these livers were determined by...

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PMID: 29949783
DOI: 10.1159/000490934

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POR

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