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Article

Correlation of Cytochrome P450 Oxidoreductase Expression with the Expression of 10 Isoforms of Cytochrome P450 in Human Liver.

Drug metabolism and disposition: the biological fate of chemicals - 1 Aug 2016

Zhang Hai-Feng, Li Zhi-Hui, Liu Jia-Yu, Liu Ting-Ting, Wang Ping, Fang Yan, Zhou Jun, Cui Ming-Zhu, Gao Na, Tian Xin, Gao Jie, Wen Qiang, Jia Lin-Jing, Qiao Hai-Ling

Abstract excerpt

Human cytochrome P450 oxidoreductase (POR) provides electrons for all microsomal cytochromes P450 (P450s) and plays an indispensable role in drug metabolism catalyzed by this family of enzymes. We evaluated 100 human liver samples and found that POR protein content varied 12.8-fold, from 12.59 to 160.97 pmol/mg, with a median value of 67.99 pmol/mg; POR mRNA expression varied by 26.4-fold. POR activity was less...

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Identifiers

PMID: 27271371
DOI: 10.1124/dmd.116.069849
PMCID: PMC4986620

Genes

POR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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