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Article

Genetic polymorphisms in cytochrome P450 oxidoreductase influence microsomal P450-catalyzed drug metabolism.

Pharmacogenetics and genomics - 1 Jan 2008

Hart Steven N, Wang Shuang, Nakamoto Kaori, Wesselman Christopher, Li Ye, Zhong Xiao-bo

Abstract excerpt

OBJECTIVES: Cytochrome P450 oxidoreductase (POR) is the only flavoprotein that donates electrons to all microsomal P450 enzymes, which catalyze the biosynthesis of steroids, fatty acids, and bile acids, as well as metabolism of more than 80% of prescription drugs. Although mutations in POR have b...

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Source

Identifiers

PMID: 18216718
DOI: 10.1097/FPC.0b013e3282f2f121

Genes

POR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18216718-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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