Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of POR haplotype distribution in African populations and comparison with other global populations.

Pharmacogenomics - 1 Sept 2022

Booyse Ross P, Twesigomwe David, Hazelhurst Scott

Abstract excerpt

Background & aim: POR is an enzyme that mediates electron transfer to enable the drug-metabolizing activity of CYP450 proteins. However, POR has been understudied in pharmacogenomics despite this vital role. This study aimed to characterize the genetic variation in POR across African populations and to compare the star allele (haplotype) distribution with that in other global populations. Materials & methods: POR...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Black People
Share to Gene Frequency

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Haplotypes

Share to Pharmacogenetics

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 36043428
DOI: 10.2217/pgs-2022-0082
PMCID: PMC9531186

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of POR haplotype distribution in African populations and comparison with other global populations.PMID 36043428Read ↗

Characterization of CYP2B6 and CYP2A6 Pharmacogenetic Variation in Sub-Saharan African Populations.Semantic proximity Read ↗

Characterization of CYP2D6 Pharmacogenetic Variation in Sub-Saharan African Populations.Semantic proximity Read ↗

Characterization of CYP2C19 pharmacogenetic variation in African populations and comparison with other global populations.Semantic proximity Read ↗

The genetic landscape of major drug metabolizing cytochrome P450 genes-an updated analysis of population-scale sequencing data.Semantic proximity Read ↗

Worldwide Distribution of Cytochrome P450 Alleles: A Meta-analysis of Population-scale Sequencing Projects.Semantic proximity Read ↗

Genetic polymorphisms in cytochrome P450 oxidoreductase influence microsomal P450-catalyzed drug metabolism.Semantic proximity Read ↗

Identification of six novel P450 oxidoreductase missense variants in Ashkenazi and Moroccan Jewish populations.Semantic proximity Read ↗

Polymorphisms in cytochrome P450 oxidoreductase and its effect on drug metabolism and efficacy.Semantic proximity Read ↗

Characterization of NAT, GST, and CYP2E1 Genetic Variation in Sub-Saharan African Populations: Implications for Treatment of Tuberculosis and Other Diseases.Semantic proximity Read ↗

Mapping the Pharmacogenetic Landscape in a Ugandan Population: Implications for Personalized Medicine in an Underrepresented Population.Semantic proximity Read ↗

Genetics of P450 oxidoreductase: sequence variation in 842 individuals of four ethnicities and activities of 15 missense mutations.Semantic proximity Read ↗

Novel SNPs in cytochrome P450 oxidoreductase.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.