Article
Genetics of P450 oxidoreductase: sequence variation in 842 individuals of four ethnicities and activities of 15 missense mutations.
Proceedings of the National Academy of Sciences of the United States of America - 5 Feb 2008
Huang Ningwu, Agrawal Vishal, Giacomini Kathleen M, Miller Walter L
Abstract excerpt
P450 oxidoreductase (POR) is an electron-donating flavoprotein required for the activity of all microsomal cytochrome P450 enzymes. We sequenced 5,655 bp of the POR gene in a representative population of 842 healthy unrelated individuals in four ethnic groups: 218 African Americans, 260 Caucasian Americans, 179 Chinese Americans, and 185 Mexican Americans. One hundred forty SNPs were detected, of which 43 were...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.