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Article

Pharmacogenetics of P450 oxidoreductase: effect of sequence variants on activities of CYP1A2 and CYP2C19.

Pharmacogenetics and genomics - 1 Jul 2008

Agrawal Vishal, Huang Ningwu, Miller Walter L

Abstract excerpt

OBJECTIVES: All microsomal cytochrome P450s enzymes, including those that metabolize the majority of clinically used drugs, require electron transfer through P450 oxidoreductase (POR). Mutations in human POR cause altered steroidogenesis and congenital malformations, but the clinical effects on drug metabolism are unclear. We examined the effects of POR sequence variants on two drug-metabolizing P450 enzymes,...

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Topics

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Share to Aryl Hydrocarbon Hydroxylases
Share to Catalysis
Share to Cytochrome P-450 CYP1A2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2C19

Share to Inactivation, Metabolic

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Share to NADPH-Ferrihemoprotein Reductase

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Source

Identifiers

PMID: 18551037
DOI: 10.1097/FPC.0b013e32830054ac

Genes

POR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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