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Polymorphisms in cytochrome P450 oxidoreductase and its effect on drug metabolism and efficacy.

Pharmacogenetics and genomics - 1 Sept 2017

Gong Liang, Zhang Cong-Min, Lv Jin-Feng, Zhou Hong-Hao, Fan Lan

Abstract excerpt

Cytochrome P450 oxidoreductase (POR) has played a potential role in the metabolism of drugs and steroids by supplying electrons to microsomal cytochrome P450 (CYP) enzymes. More than 200 different POR mutations and polymorphisms causing more than 130 amino acid changes in the POR protein have been reported since 2004. A503V is a common amino acid sequence variant encoded by POR*28, whereas A287P and R457H are the...

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Source

Identifiers

PMID: 28731962
DOI: 10.1097/FPC.0000000000000297

Genes

POR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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