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Article

Pharmacogenomics of human liver cytochrome P450 oxidoreductase: multifactorial analysis and impact on microsomal drug oxidation.

Pharmacogenomics - 1 Apr 2009

Gomes Ana M, Winter Stefan, Klein Kathrin, Turpeinen Miia, Schaeffeler Elke, Schwab Matthias, Zanger Ulrich M

Abstract excerpt

AIMS: NADPH:CYP oxidoreductase (POR) is an essential component of several enzyme systems, including the microsomal CYP monooxygenases. We investigated genetic and nongenetic POR variability and its impact on drug-oxidation activities in human liver microsomes. MATERIAL AND METHODS: POR mRNA, protein and activity, as well as ten major drug-oxidation activities, were measured in the microsomes of 150 Caucasian...

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Source

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PMID: 19374516
DOI: 10.2217/pgs.09.7

Genes

POR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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