Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of Alternative Splicing Events in HPV-Negative Head and Neck Squamous Cell Carcinoma Identifies an Oncogenic DOCK5 Variant.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Oct 2018

Liu Chao, Guo Theresa, Xu Guorong, Sakai Akihiro, Ren Shuling, Fukusumi Takahito, Ando Mizuo, Sadat Sayed, Saito Yuki, Khan Zubair, Fisch Kathleen M, Califano Joseph

Abstract excerpt

Purpose: Head and neck squamous cell carcinoma (HNSCC) is one of the most common cancers worldwide, and alternative splicing is considered to play important roles in tumor progression. Our study is designed to identify alternative splicing events (ASEs) in human papillomavirus (HPV)-negative HNSCC.Experimental Design: RNA sequencing data of 407 HPV-negative HNSCC and 38 normal samples were obtained from The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alternative Splicing
Share to Guanine Nucleotide Exchange Factors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to MAP Kinase Signaling System

Share to Oncogenes

Share to Papillomaviridae

Share to Papillomavirus Infections

Share to RNA, Small Interfering

Share to Squamous Cell Carcinoma of Head and Neck

Source

Open in PubMed Open full text

Identifiers

PMID: 29945995
DOI: 10.1158/1078-0432.CCR-18-0752
PMCID: PMC6440699

Genes

DOCK5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of Alternative Splicing Events in HPV-Negative Head and Neck Squamous Cell Carcinoma Identifies an Oncogenic DOCK5 Variant.PMID 29945995Read ↗

Genetic Drivers of Head and Neck Squamous Cell Carcinoma: Aberrant Splicing Events, Mutational Burden, HPV Infection and Future Targets.Semantic proximity Read ↗

PHF5A regulates the expression of the DOCK5 variant to promote HNSCC progression through p38 MAPK activationSemantic proximity Read ↗

Integrative Analysis of Head and Neck Cancer Identifies Two Biologically Distinct HPV and Three Non-HPV SubtypesSemantic proximity Read ↗

Distinct immune evasion in APOBEC-enriched, HPV-negative HNSCCSemantic proximity Read ↗

Distinct immune evasion in APOBEC-enriched, HPV-negative HNSCC.Semantic proximity Read ↗

Integrative and comparative genomic analysis of HPV-positive and HPV-negative head and neck squamous cell carcinomas.Semantic proximity Read ↗

Molecular heterogeneity of head and neck squamous cell carcinoma defined by next-generation sequencing.Semantic proximity Read ↗

Splicing of HPV16 E6 promotes aggressive invasion in oropharyngeal cancer via endocytosis of E-cadherinSemantic proximity Read ↗

Novel insight into mutational landscape of head and neck squamous cell carcinoma.Semantic proximity Read ↗

Signatures of somatic mutations and gene expression from p16INK4A positive head and neck squamous cell carcinomas (HNSCC).Semantic proximity Read ↗

Subtypes of HPV-Positive Head and Neck Cancers Are Associated with HPV Characteristics, Copy Number Alterations, PIK3CA Mutation, and Pathway Signatures.Semantic proximity Read ↗

Identifying predictors of HPV-related head and neck squamous cell carcinoma progression and survival through patient-derived models.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.