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Article

Signatures of somatic mutations and gene expression from p16INK4A positive head and neck squamous cell carcinomas (HNSCC).

PloS one - 1 Jan 2020

Saba Nabil F, Dinasarapu Ashok R, Magliocca Kelly R, Dwivedi Bhakti, Seby Sandra, Qin Zhaohui S, Patel Mihir, Griffith Christopher C, Wang Xu, El-Deiry Mark, Steuer Conor Ernst, Kowalski Jeanne, Shin Dong Moon, Zwick Michael E, Chen Zhuo Georgia

Abstract excerpt

Human papilloma virus (HPV) causes a subset of head and neck squamous cell carcinomas (HNSCC) of the oropharynx. We combined targeted DNA- and genome-wide RNA-sequencing to identify genetic variants and gene expression signatures respectively from patients with HNSCC including oropharyngeal squamous cell carcinomas (OPSCC). DNA and RNA were purified from 35- formalin fixed and paraffin embedded (FFPE) HNSCC tumor...

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Share to Cyclin-Dependent Kinase Inhibitor p16
Share to Databases, Nucleic Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diagnostic Tests, Routine

Share to Head and Neck Neoplasms

Share to Oropharyngeal Neoplasms

Share to Papillomaviridae

Share to Papillomavirus Infections

Share to Squamous Cell Carcinoma of Head and Neck

Source

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Identifiers

PMID: 32986729
DOI: 10.1371/journal.pone.0238497
PMCID: PMC7521680

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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