Subtypes of HPV-Positive Head and Neck Cancers Are Associated with HPV Characteristics, Copy Number Alterations, PIK3CA Mutation, and Pathway Signatures.

doi:10.1158/1078-0432.CCR-16-0323

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Article

Subtypes of HPV-Positive Head and Neck Cancers Are Associated with HPV Characteristics, Copy Number Alterations, PIK3CA Mutation, and Pathway Signatures.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Sept 2016

Zhang Yanxiao, Koneva Lada A, Virani Shama, Arthur Anna E, Virani Alisha, Hall Pelle B, Warden Charles D, Carey Thomas E, Chepeha Douglas B, Prince Mark E, McHugh Jonathan B, Wolf Gregory T, Rozek Laura S, Sartor Maureen A

Abstract excerpt

PURPOSE: There is substantial heterogeneity within human papillomavirus (HPV)-associated head and neck cancer (HNC) tumors that predispose them to different outcomes; however, the molecular heterogeneity in this subgroup is poorly characterized due to various historical reasons. EXPERIMENTAL DESIGN: We performed unsupervised gene expression clustering on deeply annotated (transcriptome and genome) HPV(+) HNC...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27091409
DOI: 10.1158/1078-0432.CCR-16-0323
PMCID: PMC5026546

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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