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Article

Integrative and comparative genomic analysis of HPV-positive and HPV-negative head and neck squamous cell carcinomas.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Feb 2015

Seiwert Tanguy Y, Zuo Zhixiang, Keck Michaela K, Khattri Arun, Pedamallu Chandra S, Stricker Thomas, Brown Christopher, Pugh Trevor J, Stojanov Petar, Cho Juok, Lawrence Michael S, Getz Gad, Brägelmann Johannes, DeBoer Rebecca, Weichselbaum Ralph R, Langerman Alexander, Portugal Louis, Blair Elizabeth, Stenson Kerstin, Lingen Mark W, Cohen Ezra E W, Vokes Everett E, White Kevin P, Hammerman Peter S

Abstract excerpt

PURPOSE: The genetic differences between human papilloma virus (HPV)-positive and -negative head and neck squamous cell carcinomas (HNSCC) remain largely unknown. To identify differential biology and novel therapeutic targets for both entities, we determined mutations and copy-number aberrations in a large cohort of locoregionally advanced HNSCC. EXPERIMENTAL DESIGN: We performed massively parallel sequencing of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25056374
DOI: 10.1158/1078-0432.CCR-13-3310
PMCID: PMC4305034

Genes

FGFR2
EGFR
FGFR1
KRAS
BRCA1
CCND1
CUL3
DDR2
EPHA2
FGFR3
NOTCH1
NSD1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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