Identifying predictors of HPV-related head and neck squamous cell carcinoma progression and survival through patient-derived models.

doi:10.1002/ijc.33125

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Article

Identifying predictors of HPV-related head and neck squamous cell carcinoma progression and survival through patient-derived models.

International journal of cancer - 1 Dec 2020

Facompre Nicole D, Rajagopalan Pavithra, Sahu Varun, Pearson Alexander T, Montone Kathleen T, James Claire D, Gleber-Netto Frederico O, Weinstein Gregory S, Jalaly Jalal, Lin Alexander, Rustgi Anil K, Nakagawa Hiroshi, Califano Joseph A, Pickering Curtis R, White Elizabeth A, Windle Bradford E, Morgan Iain M, Cohen Roger B, Gimotty Phyllis A, Basu Devraj

Abstract excerpt

Therapeutic innovation for human papilloma virus-related (HPV+) head and neck squamous cell carcinomas (HNSCCs) is impaired by inadequate preclinical models and the absence of accurate biomarkers. Our study establishes the first well-characterized panel of patient-derived xenografts (PDXs) and organoids from HPV+ HNSCCs while determining fidelity of the models to the distinguishing genetic features of this cancer...

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Identifiers

PMID: 32478869
DOI: 10.1002/ijc.33125
PMCID: PMC7554059

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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