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Article

Distinct immune evasion in APOBEC-enriched, HPV-negative HNSCC.

International journal of cancer - 15 Oct 2020

Messerschmidt Clemens, Obermayer Benedikt, Klinghammer Konrad, Ochsenreither Sebastian, Treue Denise, Stenzinger Albrecht, Glimm Hanno, Fröhling Stefan, Kindler Thomas, Brandts Christian H, Schulze-Osthoff Klaus, Weichert Wilko, Tinhofer Ingeborg, Klauschen Frederick, Keilholz Ulrich, Beule Dieter, Rieke Damian T

Abstract excerpt

Immune checkpoint inhibition leads to response in some patients with head and neck squamous cell carcinoma (HNSCC). Robust biomarkers are lacking to date. We analyzed viral status, gene expression signatures, mutational load and mutational signatures in whole exome and RNA-sequencing data of the HNSCC TCGA dataset (n = 496) and a validation set (DKTK MASTER cohort, n = 10). Public single-cell gene expression data...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32468570
DOI: 10.1002/ijc.33123

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